Resin chemistry. Membrane hydraulics. One matrix.
MonoCore™ radial-flow cellulose monoliths combine the throughput of convective membranes with the chemistry breadth and resolving power of packed-bed resins. Drop-in compatible with your FPLC.
- Channel size
- 5–100 µm
- Format
- Lab to production
- Chemistry
- AEX · CEX · HIC · Protein A
Capacity and resolution. In one matrix.
Membrane adsorbers gave the industry speed. Packed-bed resins gave it resolution. MonoCore™ delivers both — in a single cellulose monolith.
- Resin-classResolution
Sharper peaks than convective membranes — at comparable binding capacities.
- Membrane-classThroughput
Low pressure drop and short cycle times — buffer consumption drops alongside.
- Drop-inCompatibility
Standard FPLC fittings, no re-skidding — fits into the equipment your team already runs.
How MonoCore™ works
The matrix is a hydrophilic cellulose backbone with intrinsically low non-specific adsorption. Geometry is a radial-flow disc that scales by stacking — pressure drop and residence-time distribution stay constant as throughput increases. Channel size is tunable from 5 to 100 µm; chemistries cover AEX, CEX, HIC, and affinity (Protein A, custom).
Low ΔP
Pressure regime closer to membranes than to packed beds, even at high throughput.
Low void volume
Sharper peaks, less product dilution, lower buffer consumption.
Predictable scale-up
Pressure and flow profile stay consistent from lab to production — less method re-optimisation when you move volumes up.
Low fouling
The open channel architecture stays clear even with complex feeds — fewer cleaning cycles and more reproducible runs at process scale.