Resin chemistry. Membrane hydraulics. One matrix.
MonoCore™ cellulose monoliths with convective mass transport combine the throughput of membrane adsorbers with resolution comparable to packed-bed resins. Drop-in compatible with your FPLC.
- Channel size
- 15 µm
- Format
- Lab to production
- Chemistry
- AEX · CEX · HIC · Affinity
What is MonoCore™?
MonoCore™ is a line of chromatography capsules from Lumatix Biotech GmbH in Garching near Munich. Each capsule holds a monolith of modified cellulose with open 15 µm channels, through which the feed moves by convection rather than by diffusion into beads.
The line covers anion and cation exchange, HIC and affinity on one matrix, in 1.8 mL and 5.4 mL capsules that connect to a standard FPLC system. Browse the product family or read how monolithic chromatography works.
- Manufacturer
- Lumatix Biotech GmbH, Garching near Munich, Germany
- Matrix
- Modified cellulose monolith
- Channel size
- 15 µm standard; custom 10–150 µm on request
- Chemistries
- Q (AEX), S (CEX), HIC (Butyl, Phenyl), Protein A, Protein G, Custom Affinity
- Formats
- 1.8 mL and 5.4 mL capsules; larger on request
- Connection
- UNF 10/32, standard FPLC systems; max. 0.8 MPa
- Supply
- For research and process development
Capacity and resolution. In one matrix.
Membrane adsorbers gave the industry speed. Packed-bed resins gave it resolution. MonoCore™ delivers both — in a single cellulose monolith.
- Resin-classResolution
Sharper peaks than convective membranes.
- Membrane-classThroughput
Low pressure drop and short cycle times — buffer consumption drops alongside.
- Drop-inCompatibility
Standard FPLC fittings, no re-skidding — fits into the equipment your team already runs.
How MonoCore™ works
The matrix is a hydrophilic cellulose backbone with intrinsically low non-specific adsorption. Transport through the open channels is convective, so there is no intra-particle diffusion step. Pressure and flow profile stay consistent from lab to production, so there is less method re-optimisation when volumes go up. Channel size is 15 µm as standard, with other sizes from 10 to 150 µm available on request, selected per column and uniform within each monolith; chemistries cover AEX, CEX, HIC, and affinity (Protein A, Protein G, custom).
Low ΔP
Pressure regime closer to membranes than to packed beds, even at high throughput.
Low void volume
Compared with membrane adsorbers: sharper peaks, less product dilution, lower buffer consumption.
Predictable scale-up
Pressure and flow profile stay consistent from lab to production — less method re-optimisation when you move volumes up.
Low fouling
The open channel architecture stays clear even with complex feeds — fewer cleaning cycles and more reproducible runs at process scale.
Frequently asked questions
What is MonoCore™ made of?
MonoCore™ is a monolith of modified cellulose: one continuous piece of material with open channels running through it, not a bed of beads and not a stack of membranes. The standard channel size is 15 µm; custom sizes from 10 to 150 µm are made on request, selected per column and fixed within each monolith.
How does MonoCore™ compare with packed-bed resins and membrane adsorbers?
Against packed-bed resins, MonoCore™ runs faster at low pressure and copes better with demanding feeds; resolution is comparable, not better. Against membrane adsorbers, throughput is comparable, while MonoCore™ gives sharper peaks, a lower void volume and a broader choice of chemistries.
Which chemistries and formats are available?
MonoCore™ Q (strong and weak anion exchange), MonoCore™ S (strong and weak cation exchange), MonoCore™ HIC (Butyl or Phenyl), MonoCore™ Protein A, MonoCore™ Protein G and Custom Affinity with a ligand tailored to your target. All run on the same cellulose matrix in 1.8 mL and 5.4 mL capsules; larger formats are available on request.
Does MonoCore™ fit my FPLC system?
Yes. The capsules connect with standard UNF 10/32 fittings and run on the FPLC system you already use, with a maximum pressure of 0.8 MPa (8 bar) before the capsule. No re-skidding is needed.
How does MonoCore™ scale from lab to production?
Pressure and flow profile stay consistent from lab to production, so there is less method re-optimisation when volumes go up. Standard capsules are 1.8 mL and 5.4 mL; larger formats are built on request and supplied as complete capsules.
Can MonoCore™ separate full from empty AAV capsids?
We have no data of our own on full/empty separation — so we do not claim any.
Is MonoCore™ the same as Solaris® or PureLight®?
No. MonoCore™ is the cellulose monolith line in commercial supply. PureLight® is Lumatix's technology for light-controlled affinity elution, and Solaris® Protein A is the product built on it; Solaris® Protein A is in Beta, with access by application.