Resin chemistry. Membrane hydraulics. One matrix.
MonoCore™ cellulose monoliths with convective mass transport combine the throughput of membrane adsorbers with the chemistry breadth and resolving power of packed-bed resins. Drop-in compatible with your FPLC.
- Channel size
- 15 µm
- Format
- Lab to production
- Chemistry
- AEX · CEX · HIC · Protein A
Capacity and resolution. In one matrix.
Membrane adsorbers gave the industry speed. Packed-bed resins gave it resolution. MonoCore™ delivers both — in a single cellulose monolith.
- Resin-classResolution
Sharper peaks than convective membranes — at comparable binding capacities.
- Membrane-classThroughput
Low pressure drop and short cycle times — buffer consumption drops alongside.
- Drop-inCompatibility
Standard FPLC fittings, no re-skidding — fits into the equipment your team already runs.
How MonoCore™ works
The matrix is a hydrophilic cellulose backbone with intrinsically low non-specific adsorption. Transport through the open channels is convective, so there is no intra-particle diffusion step. The monolith is a disc, and it scales by stacking identical discs in one housing: throughput rises with the number of discs while the flow through each disc stays the same, so there is less to re-optimise when volumes go up. Channel size is 15 µm as standard, with other sizes from 10 to 150 µm available on request, selected per column and uniform within each monolith; chemistries cover AEX, CEX, HIC, and affinity (Protein A, Protein G, custom).
Low ΔP
Pressure regime closer to membranes than to packed beds, even at high throughput.
Low void volume
Compared with membrane adsorbers: sharper peaks, less product dilution, lower buffer consumption.
Predictable scale-up
Pressure and flow profile stay consistent from lab to production — less method re-optimisation when you move volumes up.
Low fouling
The open channel architecture stays clear even with complex feeds — fewer cleaning cycles and more reproducible runs at process scale.