Fast, robust chromatography for proteins, viral vectors and nucleic acids.
MonoCore™ cross-linked cellulose monoliths combine convective transport with open 15 µm channels — short runs at low pressure, and a structure that copes with demanding feeds. Anion and cation exchange, HIC and affinity, ready to connect to the FPLC system you already run.
Know what you need? Request a quote
Resin-class resolution at convective throughput.
- Channel size15 µmcustom 10–150 µm on request
- Formats1.8 & 5.4 mLlarger on request
- ChemistriesSixone cellulose matrix
- IntegrationDrop-in FPLCUNF 10/32
- EXIST ForschungstransferFederal Ministry for Economic Affairs (BMWK)
- KMU-innovativ: BioeconomyFederal Ministry of Research (BMBF)
- ACHEMA Start-up Award 2022Winner
Three bottlenecks MonoCore™ is built to remove.
Packed beds hit a pressure wall.
Transport through open channels is convective, so runs stay short and pressure stays low — at flow rates a packed bed cannot reach within its pressure limit.
Convective vs diffusive transport →Media clog on demanding feeds.
Packed beds, membrane adsorbers and fibre-based media all push the feed through narrow flow paths — and that is where demanding feeds block. MonoCore™ ships with 15 µm open channels, well above the published 3.5 µm threshold below which large plasmids start to clog.
Why channel size matters →New media means re-skidding.
Standard UNF 10/32 fittings. MonoCore™ capsules connect to the FPLC system your team already runs — no custom hardware.
How MonoCore™ works →
Six chemistries on one cellulose matrix.
MonoCore™ Q
Strong & Weak Anion Exchange
MonoCore™ S
Strong & Weak Cation Exchange
MonoCore™ HIC
Butyl and Phenyl
MonoCore™ Protein A
Protein A
MonoCore™ Protein G
Protein G
Custom Affinity
Affinity
From first question to data on your own system.
- 01
Talk it through
A short conversation about your molecule, your feed and the method you run today.
- 02
Get a scoped quote
Chemistry, capsule format and evaluation scope — matched to the question you want answered.
- 03
Run it on your FPLC
Capsules arrive ready to connect, with an operating guide and direct support for method setup.
- 04
Review the data together
We go through the chromatograms with you and agree what the next step should be.
Built for the modalities where scale-up gets harder.
AAV / LVV
Polishing and impurity removal for adeno-associated virus and lentiviral vectors at process-relevant flow rates.
Read application →pDNA / mRNA
Intermediate purification for plasmid DNA and mRNA — open channels for large plasmids, short runs, low buffer load.
Read application →mAb & antibody modalities
Polishing for monoclonals and complex antibody modalities with resin-class peak resolution at membrane-class throughput.
Read application →
Recent articles.
- How-to guide
Which chromatography media are suitable for AAV polishing?
After affinity capture, AAV polishing removes residual host cell protein and DNA and enriches full capsids over empty ones. Because an AAV capsid is roughly 25 nm across, it barely enters the pores of a packed-bed resin — so convective media are the usual choice. MonoCore™ Q and MonoCore™ S are cross-linked cellulose monoliths with a 15 µm channel size in 1.8 mL and 5.4 mL capsules with UNF 10-32 connectors.
- Comparison guide
Alternatives to membrane adsorbers — what else runs at convective speed?
If a membrane adsorber is not the right fit, the closest alternative in the same speed class is a monolith. Both are convective media. MonoCore™ is a cross-linked cellulose monolith available as Q and S, HIC with butyl and phenyl ligands, Protein A and Protein G, with a 15 µm channel size in 1.8 mL and 5.4 mL capsules with UNF 10-32 connectors.
- Article
Why chromatography media foul when you load a biological feed
Fouling in a bioprocess purification step is rarely the ligand's fault. Where debris, DNA and denatured protein end up depends on the geometry of the medium. Adsorptive membranes work in the range of roughly 0.8 to 5 um; MonoCore capsules run a 15 um channel as standard, about an order of magnitude wider, with a continuous flow path rather than a stack of layers.
Test MonoCore™ on your own process.
Tell us your molecule, your feed and the method you run today. A scientist gets back to you within two business days with a fitting chemistry and an evaluation scope.