Fast, robust chromatography for proteins, viral vectors and nucleic acids.
MonoCore™ modified cellulose monoliths combine convective transport with open 15 µm channels — short runs at low pressure, and a structure that copes with demanding feeds. Anion and cation exchange, HIC and affinity, ready to connect to the FPLC system you already run.
Know what you need? Request a quote
Resin-class resolution at convective throughput.
- Channel size15 µmcustom 10–150 µm on request
- Formats1.8 & 5.4 mLlarger on request
- ChemistriesSixone cellulose matrix
- IntegrationDrop-in FPLCUNF 10/32
- EXIST ForschungstransferFederal Ministry for Economic Affairs and Energy (BMWE)
- KMU-innovativ: BioeconomyFederal Ministry of Research, Technology and Space (BMFTR)
- ACHEMA Start-up Award 2022Winner
Three bottlenecks MonoCore™ is built to remove.
Packed beds hit a pressure wall.
Transport through open channels is convective, so runs stay short and pressure stays low — at flow rates a packed bed cannot reach within its pressure limit.
Convective vs diffusive transport →Media clog on demanding feeds.
On a porous bead the binding surface sits inside pores that are far narrower than the space between the beads, so a large molecule has to diffuse into a constriction to reach it. A monolith has one length scale instead of two: the channel the feed flows through is the channel the molecule binds in. MonoCore™ ships with 15 µm channels, and published work on large plasmids puts the point where a channel starts to hinder them at a few micrometres.
Why channel size matters →New media means re-skidding.
Standard UNF 10/32 fittings. MonoCore™ capsules connect to the FPLC system your team already runs — no custom hardware.
How MonoCore™ works →
Five chemistries and a blank matrix, on one cellulose backbone.
MonoCore™ Q
Strong & Weak Anion Exchange
MonoCore™ S
Strong & Weak Cation Exchange
MonoCore™ HIC
Butyl and Phenyl
MonoCore™ Protein A
Protein A
MonoCore™ Protein G
Protein G
Custom Affinity
Affinity
From first question to data on your own system.
- 01
Talk it through
A short conversation about your molecule, your feed and the method you run today.
- 02
Get a scoped quote
Chemistry, capsule format and evaluation scope — matched to the question you want answered.
- 03
Run it on your FPLC
Capsules arrive ready to connect, with an operating guide and direct support for method setup.
- 04
Review the data together
We go through the chromatograms with you and agree what the next step should be.
From antibodies to viral vectors — one matrix, five chemistries.
Chromatography for antibody purification
The platform process for monoclonals, and where bispecifics, ADCs and fragments depart from it. Which chromatography step does what, and what to change when the standard route stops working.
Read application →Recombinant protein purification
Enzymes, growth factors, vaccine antigens, fusion proteins — the work is the same shape every time: separate one protein from everything the host made alongside it. Which chemistry does that, and where the feed decides the route.
Read application →AAV and viral vector purification
Adeno-associated and lentiviral vectors, from clarified harvest to formulated product — and the separation that has no equivalent in any other process: full capsids from empty ones.
Read application →
Recent articles.
- Article
What is rapid cycling chromatography?
Running a small column many times instead of a large one once — how bioprocess intensification works in a capture step, what it costs in cycles and cleaning, and when a packed bed is simply the better answer.
- Article
AAV purification: the protocol, step by step
From harvest to formulated vector: lysis or supernatant, clarification, affinity capture, the full/empty separation on anion exchange, polishing and concentration — with the decision behind each step and where the route differs by serotype.
- Article
Antibody purification: how the standard route works
Capture, virus inactivation, polishing, virus filtration, formulation — the route that gets a monoclonal antibody from harvest to drug substance, the decision behind each step, and where it differs for hybridoma, bispecific and Fc-fusion formats.
Test MonoCore™ on your own process.
Tell us your molecule, your feed and the method you run today. A scientist gets back to you within two business days with a fitting chemistry and an evaluation scope.